Titolo: TNF-α and IL-10 modulation induced by polyphenols extracted by olive pomace in a mouse model of paw inflammation.
Autori: Carito V, Ciafrè S, Tarani L, Ceccanti M, Natella F, Iannitelli A, Tirassa P, Chaldakov GN, Ceccanti M, Boccardo C, Fiore M.
Pubblicazione: Ottobre 2015
Abstract
BACKGROUND
Polyphenols from olive are known to possess antioxidant and anti-inflammatory properties.
AIM
The aim of this study was to study whether or not 10 consecutive days i.p. administration of a blend of olive (Olea europaea L.) polyphenols (10 mg/kg) containing mostly hydroxytyrosol could have an effect on cytokines playing important roles in inflammatory processes as TNF-α and IL-10.
MATERIALS AND METHODS
Inflammation was induced in the mouse paw by 2 carrageenan injections (50 µl vol, 5 mg/kg each). TNF-α and IL-10 were measured by enzyme-linked immunosorbent assay.
RESULTS
Carrageenan decreased IL-10 in the paws, however, this reduction appeared to be less evident in mice treated with carrageenan but administered with polyphenols. As for TNF-α, our findings did not reveal differences between groups but an increase in the polyphenol and carrageenan group if compared to the carrageenan only group. As for antioxidant polyphenols’ properties, no differences between groups in the serum glutathione were found.
CONCLUSIONS
Altogether, this investigation shows that olive polyphenols in the mouse may modulate the levels of cytokines having a role in the process of inflammation as TNF-α and IL-10.
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